typical belly fat

Leptin Studies Reveal Key Ways to Avoid Being Overweight & Cancer.

by Circkles.com

First of All, What is Leptin?

Leptin is a hormone that is produced by the fat cells in the body. Its main role is regulating how many calories we eat and burn, as well as how much fat we carry on our bodies. Leptin was discovered in 1995, and has since been of great interest to scientists seeking new treatments for Type 2 diabetes and obesity. Leptin, like insulin is a hormone. It is part of a network of regulatory hormones which control how energy is consumed and used up in the body. Resistance to leptin, or a lack of it, have been proven to cause obesity in many research studies..

How Do You Become Leptin Resistant?

Oddly enough, the same way you become insulin resistant – by continuous overexposure to high levels of the hormone caused by a diet that is high in sugar (particularly fructose), grains, and processed foods. This same type of diet will also increase inflammation in your body, now being shown in studies to increase your risk of cancer, and as the sugar gets metabolized in your fat cells, the fat releases surges in leptin.
Over time, if your body is exposed to too much leptin, it will become resistant, just as your body can become resistant to insulin thereby causing diabetes.
The only known way to reestablish proper leptin (and insulin) signaling is to prevent those surges, and the only known way to do that is via diet. Diet can have a more profound effect on your health than any other known modality of medical treatment.

Obesity Also Increases Cancer's Growth.

At least 20 different diseases and conditions are directly attributable to being overweight. One disease related to excess weight is cancer. And according to recent research, being obese promotes the growth of existing tumors regardless of diet, which may help explain why lean cancer patients often have better outcomes than their obese counterparts.

An animal study, published in the Oct. 15 issue of the journal Cancer Research, showed that tumors in obese mice grew much faster than in lean mice eating the same diet. According to the authors:

"In this study, we show that obesity facilitates tumor growth in mice irrespective of concurrent diet, suggesting a direct effect of excess white adipose tissue [fat tissue]. When transplanted into mice, adipose stromal cells can serve as perivascular adipocyte progenitors that promote tumor growth, perhaps helping explain the obesity-cancer link."
The researchers discovered that the presence of cancer triggered adipose stromal cells – "white" fat cells – to migrate into the blood stream. Once these cells come across a tumor, some of them help provide oxygen and nutrients to the tumor, thereby feeding the growth of the cancer.

Lead researcher Mikhail Kolonin told MedicineNet:
"The fact that these cells are present in tumors is still an emerging concept. We have shown that not only are they present, but they are also functional and affect tumor growth. Identifying the signals that cause these cells to be recruited to tumors and finding ways to block them might provide a new avenue of cancer treatment."

The Vicious Cycle.

When the brain doesn’t receive the leptin signal, it erroneously thinks that the body is starving, even though it has more than enough energy stored .Losing weight reduces fat mass, which leads to a significant reduction in leptin levels, but the brain doesn’t necessarily reverse its leptin resistance. When leptin goes down, this leads to hunger, increased appetite, reduced motivation to exercise and decreased amount of calories burned at rest.
Basically, the reduced leptin makes the brain think it is starving… so it initiates all sorts of powerful mechanisms to regain that lost body fat, erroneously thinking that it is protecting us from starvation.
This makes the brain change our physiology and behavior in order to regain the fat that the brain thinks we’re missing.

• Eating More: The brain thinks that we MUST eat so that we don’t starve to death.

• Reduced Energy Expenditure: The brain thinks we need to conserve energy, so it makes us feel lazier and makes us burn fewer calories at rest.
In this way… eating more and exercising less is not the cause of weight gain, it is the consequence of leptin resistance, a hormonal defect.
For the great majority of people, trying to exert cognitive inhibition (willpower) over the leptin-driven starvation signal is next to impossible.

According to Dr. Guyenet (see video below), several cellular mechanisms behind leptin resistance have been identified.
These include:

1. Inflammation: Inflammatory signalling in the hypothalamus is likely an important cause of leptin resistance in both animals and humans.
3. Free Fatty Acids: Having elevated free fatty acids in the bloodstream may increase fat metabolites in the brain and interfere with leptin signalling.
5. Having high leptin: Having elevated levels of leptin in the first place seems to cause leptin resistance.
Pretty much all of these factors are increased in obesity… so this may form a vicious cycle where people get fatter and increasingly more leptin resistant over time.

All three of these factors are increased in obesity.

obese mice vs normal mouse

What Science Knows About Reversing Leptin Resistance

The best way to know if you are leptin resistant, is to look in the mirror. If you have a lot of body fat, especially in the belly area, then you are almost certainly leptin resistant. A key to preventing (or reversing) leptin resistance, is eliminating an inflammatory diet, which will not just lower your leptin resistance, but cancer risk, diabetes and a large number of other diseases.

To Lower Your Bodily Inflammation:

• Avoid processed food: Highly processed foods compromise the integrity of the friendly flora in the gut and start inflammation.

• Eating soluble fiber can help improve gut health and may protect against obesity.

• Physical activity can help to reverse leptin resistance, increase metabolism, decrease diabetes, regulate hormone levels and help overall health.

• Poor sleep has been implicated in problems with leptin, so do whatever it takes to get 6-8 hours of quality sleep.

• Lower your triglycerides: Having high blood triglycerides can prevent the transport of leptin from blood and into the brain. The best way to lower triglycerides is to reduce carbohydrate intake.

• Limit your daily fruit intake to 1-2 servings per day. That includes fruit juices and dried fruits like raisins, and watch those fruit smoothies. There are some benefits to eating fruit, such as bananas are a good source of potassium, raisins are high in iron, many fruits are powerful antioxidants etc., but lower your daily intake of these high-fructose foods and you will likely see a drop in weight without even increasing your exercise much.

• Eat Protein: Eating plenty of protein can cause automatic weight loss. There are many reason for that, one of them may be an improvement in leptin sensitivity.

• Eat a regular anti-inflammatory diet. Anything that creates or promotes inflammation in the body increases the risk for cancer and numerous other diseases. Current research suggests cancer is actually a chronic inflammatory disease. The inflammatory process creates an environment in which abnormal cells proliferate.

• Cancer cells require the glucose in carbohydrates to grow and multiply, so you want to limit or eliminate that cancer energy source. Carbs to remove from your diet include processed grains, fruits with fructose, and starchy vegetables like potatoes. Keep in mind that some starch and carbs are necessary, but make them high-quality and low quantity.
Cancer cells generally can't use dietary fats for energy, so appropriate amounts of good-quality fats are nutritionally healthy, like from avocados, Omega 3, olive and grapeseed oils. That natural fats and oils in vegetables are best, especially if they are not highly processed.

What this all points to, once again, is that vegetables are the key to health. So we suggest you start getting very creative with them. Following our Recipe Club Blog can help, and all of our monthly Health Circkles articles are written with the ultimate diet in mind, so following Circkles will help as well.

In the video below, Dr. Stephan Guyenet, an obesity researcher, explains in further detail about leptin and how it is implicated in obesity.



Foods That Heal: Lemon.

by Circkles.com.

lemonsTherapeutic Properties: Very good for breaking up phlegm in the throat or using as a nasal spray (see Home Remedies). Lemon is very cleansing and will act as a detoxing agent in the body. It is also reported that lemon juice can clear up age spots, but this takes months to really work. Astringent and contains antioxidants that help fight cancer.

Acid or Alkaline: Very alkaline. Most people think of lemon as being acidic, but it has an alkaline effect on the body PH.

Significant Nutrients: High in vitamin C, potassium.

Phytoestrogen: No

How to Grow: You can grow lemon in front of a sunny window in a pot in your house or in a greenhouse. Get the miniature lemon trees (Meyer lemon is one). Although, it takes about a year for a lemon to get ripe.

How to Use: Squeeze the juice from a fresh lemon in many things such as drinks, or on salads. You can also make a tea by steeping a thick slice of lemon in water and adding honey and cinnamon.





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This health section is updated monthly to give our members a chance to view it, so check back the first of every month for new posts. Disclaimer: This page is designed to offer information only on topics the average person can use themselves. It is not meant to be a substitute for professional medical advice.

We are so far removed from what it is that we need to be healthy, that we are not healthy as a general society. To make matters worse, we are so used to functioning at an inferior health level, we are not even aware how much better we could feel, how much healthier we could be, how much more energy we should have, how much younger we could look, until we take the steps in the right direction and give them a chance to work so we have a comparison. The only way to experience this is to try something different; because what we've been doing obviously isn't working.
Getting back to basics, back to nutrition over convenience and making our own choices rather than advertising and corporations making our decisions for us, and back to logic are the only things that will restore our health, energy and vitality. There is no reason a healthy lifestyle has to be one of denying ourselves or inconvenience.
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"The Doctor of the future will give no medicine but will interest his patients in the care of the human frame, in diet, and in the cause and prevention of disease."
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